Related Experiment Videos
Selective deoxygenation of leurosine: concise access to anhydrovinblastine
Christophe Hardouin1, Eric Doris, Bernard Rousseau
1CEA/Saclay, Service de Marquage Moléculaire et de Chimie Bioorganique, Bât. 547, Département de Biologie Joliot-Curie, 91191 Gif sur Yvette Cedex, France.
The Journal of Organic Chemistry
|August 31, 2002
Abstract:
Straightforward access to anhydrovinblastine starting from the parent alkaloid leurosine is reported. The key deoxygenation step was first optimized on a model substrate. However, applied to leurosine, only the low-valent Cp2TiCl gave satisfactory results.