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NSAIDs in dermatologic therapy: review and preview
Edward S Friedman1, Nicole LaNatra, Matthew J Stiller
1Department of Dermatology, Columbia-Presbyterian Medical Center, New York, New York, USA.
Journal of Cutaneous Medicine and Surgery
|August 31, 2002
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) are effective for treating various skin conditions. Emerging research suggests NSAIDs may also prevent non-melanoma skin cancer, with COX-2 inhibitors offering promising therapeutic potential.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Nonsteroidal anti-inflammatory drugs (NSAIDs) have been utilized for over 30 years in treating numerous skin conditions.
- NSAIDs function by inhibiting prostaglandin synthesis via the cyclooxygenase (COX) pathway.
Purpose of the Study:
- To review the application of NSAIDs in over 15 dermatological conditions.
- To explore the expanding role of NSAIDs in dermatology, including potential anti-cancer effects.
Main Methods:
- Retrospective review of NSAID use in various dermatoses.
- Analysis of the mechanism of action involving prostaglandin synthesis inhibition.
Main Results:
- NSAIDs are effective in managing conditions such as acne, psoriasis, sunburn, and vasculitis.
- Recent findings indicate a link between prostaglandins and skin cancer development.
Conclusions:
- NSAIDs show potential in treating and preventing non-melanoma skin cancer.
- Selective COX-2 inhibitors may offer safer and more effective long-term dermatological treatment options.