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Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives
C Dinkel1, M Moody, A Traynor-Kaplan
1Institut für Organische Chemie, Universität Bremen, UFT Leobener Strasse, 28359 Bremen, Germany.
Angewandte Chemie (International Ed. in English)
|August 31, 2002
Abstract:
A crucial role in the regulation of epithelial chloride secretion is played by the phosphoinositide PtdIns(3,4,5)P3 . Membrane-permeant derivatives of this and other naturally occurring phosphoinositides have been synthesized. These derivatives, which can be bioactivated, were used in investigations on nasal epithelia of patients suffering from cystic fibrosis.