Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poly(L-glutamic acid)--anticancer drug conjugates.

Chun Li1

  • 1Department of Experimental Diagnostic Imaging, Box 59, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. cli@di.mdacc.tmc.edu

Advanced Drug Delivery Reviews
|September 3, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.

Nature genetics·2014
Same author

[Chemical constituents from a Tibetan medicine Meconopsis horridula].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2014
Same author

[Chemical constituents from whole plants of Aconitum tanguticum (III)].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2014
Same author

Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation.

BMC complementary and alternative medicine·2014
Same author

A versatile complementation assay for cell-to-cell and long distance movements by cucumber mosaic virus based agro-infiltration.

Virus research·2014
Same author

Composition of EPS fractions from suspended sludge and biofilm and their roles in microbial cell aggregation.

Chemosphere·2014
Same journal

Silicone oil in protein drug products and its implications for formulation stability.

Advanced drug delivery reviews·2026
Same journal

Targeted delivery of proteolysis-targeting chimeras (PROTAC) and molecular glue degraders (MGD).

Advanced drug delivery reviews·2026
Same journal

Lysosome-targeting degrader delivery system: from formulation design to biomedical applications.

Advanced drug delivery reviews·2026
Same journal

Anti-PEG antibodies in nanomedicine: Mechanisms, risks, and opportunities.

Advanced drug delivery reviews·2026
Same journal

Optimizing macrophage-targeted intracellular delivery systems for safe and effective immunotherapies.

Advanced drug delivery reviews·2026
Same journal

Light-controlled CRISPR-dCas9 epigenome editing: advanced drug-delivery strategies and oncology applications.

Advanced drug delivery reviews·2026
See all related articles

Polymer drug conjugates offer a promising approach to cancer therapy by reducing toxicity. Poly(L-glutamic acid) based conjugates show potential for targeted delivery and improved treatment outcomes.

Area of Science:

  • Polymer Chemistry
  • Oncology
  • Drug Delivery Systems

Background:

  • Chemotherapy faces limitations due to toxicity to normal cells.
  • Polymer conjugates offer a synthetic strategy to improve cancer treatment.
  • Polymeric chemotherapeutic agents are advancing into clinical studies.

Purpose of the Study:

  • To review poly(L-glutamic acid) based polymeric chemotherapeutic agents.
  • To discuss their chemistry, properties, and therapeutic applications.
  • To explore targeted delivery strategies using poly(L-glutamic acid) as a drug carrier.

Main Methods:

  • Review of existing literature on poly(L-glutamic acid) conjugates.
  • Analysis of chemical synthesis and physicochemical properties.
  • Evaluation of therapeutic applications and targeted delivery mechanisms.

Related Experiment Videos

Main Results:

  • Poly(L-glutamic acid) serves as a versatile platform for anticancer drug conjugation.
  • These conjugates demonstrate improved therapeutic efficacy and reduced systemic toxicity.
  • Innovative polymeric constructs enhance targeted drug delivery to tumors.

Conclusions:

  • Poly(L-glutamic acid) based polymer conjugates represent a significant advancement in cancer therapy.
  • Their tailored design facilitates targeted delivery and minimizes side effects.
  • Further development of these constructs holds promise for more effective cancer treatments.