Related Experiment Video
Updated: Aug 10, 2026

A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect
Published on: September 22, 2023
Early introduction of oral feeding in preterm infants
Chanda Simpson1, Richard J Schanler, Chantal Lau
1Pediatrix Medical Group of Texas, PA, Fort Worth, Texas, USA.
Insights
Early oral feeding in preterm infants significantly shortens the transition time from tube to full oral feeding. This approach accelerates feeding milestones and enhances oral motor skills for successful infant nutrition.
Area of Science:
- Neonatal Nutrition and Feeding Practices
- Pediatric Gastroenterology
- Infant Development
Background:
- Preterm infants often require prolonged tube feeding due to immature oral feeding skills.
- Transitioning from tube to oral feeding is a critical developmental milestone.
- Optimizing this transition is essential for infant growth and well-being.
Purpose of the Study:
- To evaluate if early introduction of oral feeding accelerates the transition from tube to all oral feeding in preterm infants.
- To determine if this intervention leads to earlier achievement of full oral feeding.
Main Methods:
- A randomized controlled trial involving 29 preterm infants (<30 weeks' gestation).
- Intervention group received early oral feeding initiation post-full tube feeding; control group received standard care.
- Feeding milestones, overall transfer, and milk transfer rate were monitored.
Main Results:
- The intervention group started oral feeding earlier (31.1 vs. 33.7 weeks postmenstrual age) and achieved all oral feeding sooner (34.5 vs. 36.0 weeks).
- Transition time was significantly reduced in the intervention group (26.8 vs. 38.4 days).
- Oral motor skill indicators (overall transfer and milk transfer rate) were comparable between groups.
Conclusions:
- Early oral feeding introduction effectively accelerates the transition from tube to all oral feeding in preterm infants.
- This strategy facilitates earlier attainment of oral feeding and improves oral motor skill development.
- Early intervention supports safer and more successful infant feeding outcomes.
Objective:
To determine whether transition from tube to all oral feeding can be accelerated by the early introduction of oral feeding in preterm infants. It is hypothesized that this shortened transition time will lead to earlier attainment of all oral feeding.
Design:
Twenty-nine infants (<30 weeks' gestation) were randomized to an intervention or control group. The intervention group (n = 13) was initiated to oral feeding 48 hours after achieving full tube feeding (120 kcal/kg/d), and the feeding progression followed a structured protocol. The oral feeding management of the control infants (n = 16) was left to the discretion of their attending physicians. Oral feeding progress was monitored for achievement of selected feeding milestones: achievement of first and all successful oral feedings. Feeding performance was assessed by overall transfer (percent volume transferred during a feeding/total volume offered) and rate of milk transfer (mL/min), which were measured from introduction of oral feeding to first successful oral feeding.
Results:
Infants in the experimental group, when compared with their control counterparts, were introduced to oral feeding significantly earlier (31.1 +/- 1.3 vs 33.7 +/- 0.9 weeks' postmenstrual age, respectively) and attained all oral feeding significantly earlier as well (34.5 +/- 1.6 vs 36.0 +/- 1.5 weeks' postmenstrual age, respectively). The transition time from full tube feeding to all oral feeding was 26.8 +/- 12.3 days for the experimental group and 38.4 +/- 14.0 days for the control group. Both groups of infants demonstrated similar increase in overall transfer and rate of milk transfer from introduction of oral feeding until achievement of first successful oral feeding.
Conclusions:
Early introduction of oral feeding accelerates the transition time from tube to all oral feeding. This not only allows earlier attainment of all oral feeding, but it also provides practice opportunities that enhance the oral motor skills necessary for safe and successful feeding.
Related Concept Videos
The Early Endosome: Endocytosis of Transferrin
Preclinical Development: Overview
Enteral Nutrition I: Orogastric and Nasogastric Feeding
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube through...
Oral Drug Delivery Systems: Introduction
Development of the Oral Microbiota

