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[Inhibitory effect of paeonol on experimental atherosclerosis in quails]
Abstract
Objective:
To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding.
Method:
The effects of oral administration of 300 and 600 mg/kg of paeonol on lipid levels in serum, hemorrheology and aortic intimal abnormalities were investigated.
Result:
Paeonol decreased TC, TG, LDL, vLDL, APOB100 levels in serum and TC levels in aorta and liver. The ratios of HDL/TC, HDL2/HDL3, apoA1/apoB100 were elevated. In addition, the drug reduced the whole blood viscosity, Plasma viscosity and plasma fibrinogen, and inhibited erythrocyte aggregation.
Conclusion:
Oral administration of paeonol can reduce the development of atherosclerosis.