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Updated: Sep 29, 2026

Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
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[Intracerebral distribution of albumin after closed brain traumas]

M Liu1, Z Liao, J Wu

  • 1Department of Forensic Pathology, WCUMS, Chengdu 610041.

Hua Xi Yi Ke Da Xue Xue Bao = Journal of West China University of Medical Sciences = Huaxi Yike Daxue Xuebao
|September 11, 2002
PubMed

Twenty cases of closed brain traumas were investigated immunohistochemically to detect intracerebral distribution of albumin. The brain contusions' areas were heavily stained in all cases, even in those of only 15 minutes' survival. Some neurons, nerve fibers, astrocytes and gitter cells of the softening area both nearby the contusion areas and far from the contusion areas, including thalamus, midbrain, pons and medulla, were also heavily stained in all cases. The marked immunoreactivity to albumin also took place in extravascular spaces, endothelial cells and membrane of red blood cells. The results suggested that immunohistochemical staining of albumin should be a sign of early brain trauma, inclusive of brainstem trauma. It is especially useful in the identification of brain traumas without bleeding.

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