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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
[Expression of C-erbB-2 protein in breast cancer and its clinical significance]
1Department of General Surgery, First Affiliated Hospital, WCUMS, Chengdu 610041.
Abstract:
In order to understand the expression of C-erbB-2 protein in breast cancer and its clinical significance, we examined the expression of C-erbB-2 protein in 106 breast carcinomas by using the immunohistochemical techniques LSAB. The results showed that the positive rate of C-erbB-2 expression was 63.21% (67/106). The overexpression of C-erbB-2 protein related negatively with survival. 81.63% of the cases with overexpression of C-erbB-2 protein survived < or = 5 years and 34.29% survived > 10 years. There were significant associations of C-erbB-2 overexpression with advanced clinical stage, high histological grade, and positive axillary node status in breast cancers. All of these findings suggested that overexpression of C-erbB-2 protein might be an important prognostic factor and the detection of C-erbB-2 protein might be arranged as a regular pathological examination in the cases of breast cancer.
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