Related Experiment Videos
[Effects of Rg1 on calcium channel of guinea pig ventricular myocytes]
1ICU, Hospital of Chinese Traditional Medicine of Guangdong Province, Fu Shan 528000.
Abstract
Objective:
To evaluate the effect of Rg1 (purified saponin of Panax notoginseng) on L-Ca2+ channel of guinea pig ventricular myocytes.
Method:
The whole-cell patch clamp recording technique.
Result:
When the holding potential was kept at -40 mV, and the cell was depolarized to +40 mV for 150 ms at a frequency of 0.5 Hz.Rg1 10 mumol.L-1 and 30 mumol.L-1 could not reduce Bay K 8644 and nifedipine-sensitive L-type Ca2+ inward current (P > 0.05, n = 5).
Conclusion:
Rg1 should not be a Ca2+ channel antagonist.