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[Expression of bcl-2 in acute leukemia patients and its significance]
1Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University
|September 11, 2002
Abstract
Unlabelled:
RT-PCR method was used to detect the expression level of bcl-2 gene in 38 patients of acute leukemia.
Results:
Expression level of bcl-2 in the patients with clinical refractoriness increased more obviously than previously untreated and CR patients, and the expression level of bcl-2 was obviously correlated with clinical refractoriness(r = 0.83, P < 0.01), which indicated that high expression of bcl-2 was one of the factors in clinical refractoriness. It was also a sensitive method for predicting the effect of anti-tumor agents and prognosis in clinic work.