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Updated: Aug 19, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Levels of plasma TF and TFPI activities in patients with acute leukemia]
1Department of Haemotology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Objective:
To investigate the changes of plasma tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in the patients with acute leukemia.
Methods:
TF and TFPI activities were measured by using chromogenic assays.
Results:
Plasma TF activity in the patients with acute leukemia was higher and TFPI activity was lower than those in normal(P < 0.01). In 7 patients who underwent the first chemotherapy, the plasma TF activity was decreased after chemotherapy(P < 0.01), while TFPI activity increased(P < 0.05).
Conclusion:
The unbalance between plasma TF and TFPI activities contributes to the coagulant disorders in acute leukemia.
