[A quantitative analysis of renal pathology in the children with anaphylactoid purpura nephritis (APN)]

To provide the theoretical value for the treatment and prognostic judgement of APN.

All cases were scored on the pathologic change of glomeruli and tubules.

The pathologic scores of glomeruli in 30 cases were as follows: no one on Grade 0; 6(20%) on Grade 1; 17(56.7%) on Grade 2 and 7 (23.3%) on Grade 3. The pathologic scores of tubule were: Grade 0 was 2(6.7%); Grade 1 was 6(20%); Grade 2 was 14(46.7%); Grade 3 was 8(26.7%). There was positive correlation between glomerulus and tubule pathologic degree(r = 0.783, P < 0.01). The pathologic score of nephrotic syndrome in clinical manifestation was higher than that of non-nephrotic syndrome(P < 0.01). There was no significant difference in glomerular pathologic score between the simple urinary protein group and acute glomerulonephritis(AGN) group(P > 0.05), but tubular pathologic score in simple urinary proteins group was higher than that of AGN and essential hematuria group (P < 0.01, P < 0.05). The pathologic score of kidney(including glomerulus and tubule) was positively correlated with the disease course(r = 0.563, P < 0.01), but not with serum urea nitrogen and creatinine(r = 0.281, r = 0.236, P > 0.05).

Serious tubular pathologic changes(not only glomerular pathologic change, but also tubular pathologic change in the APN children) were found in the patients with nephrotic syndrome and simple urinary proteins. Long-term urinary protein and the recurrence of the disease may be the important risk factor in kidney pathologic of APN.