Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kernicterus: an international perspective.

Thor Willy Ruud Hansen1

  • 1Section on Neonatology, Department of Pediatrics, Rikshospitalet, University of Oslo, Norway. t.w.r.hansen@klinmed.uo.no

Seminars in Neonatology : SN
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Professor Dag Bratlid (1944-2025)-a tribute.

Pediatric research·2025
Same author

[Alternative pathways to knowledge beyond randomised trials].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2025
Same author

Blue-Green (~480 nm) versus Blue (~460 nm) Light for Newborn Phototherapy-Safety Considerations.

International journal of molecular sciences·2023
Same author

International guidelines regarding the role of intravenous immunoglobulin in the management of RhD- and ABO-mediated haemolytic disease of the newborn-reconsidering the recommendations.

British journal of haematology·2022
Same author

Illegitimacy Before and Now: The Times They Are A'Changin'.

Neonatology·2022
Same author

Continuous Deep Sedation in the Newborn: Knowledge and Need.

Neonatology·2021
Same journal

Role of micro-organisms in necrotizing enterocolitis.

Seminars in neonatology : SN·2020
Same journal

The epidemiology and pathogenesis of necrotizing enterocolitis.

Seminars in neonatology : SN·2020
Same journal

Regionalized perinatal education.

Seminars in neonatology : SN·2005
Same journal

Regional quality assessment in perinatal care.

Seminars in neonatology : SN·2005
Same journal

Regionalized long-term follow-up.

Seminars in neonatology : SN·2005
Same journal

Regionalized neonatal emergency transport.

Seminars in neonatology : SN·2005
See all related articles

Kernicterus, a severe form of newborn jaundice, appears to be increasing due to decreased vigilance and early discharge. Early recognition and intervention for neonatal jaundice are crucial to prevent bilirubin-induced brain damage.

Area of Science:

  • Neonatology
  • Pediatric Neurology
  • Public Health

Background:

  • Kernicterus is a global concern, with increased risk in regions with high prevalence of glucose-6-phosphate dehydrogenase deficiency.
  • A rise in kernicterus case reports in the 1990s suggests potential contributing factors like reduced vigilance for newborn jaundice and inadequate post-discharge follow-up.
  • Current limitations exist in identifying infants particularly vulnerable to bilirubin's neurotoxic effects.

Purpose of the Study:

  • To highlight the potential increase in kernicterus incidence.
  • To emphasize the need for vigilant evaluation of jaundiced newborns.
  • To advocate for improved strategies in managing neonatal jaundice and preventing bilirubin encephalopathy.

Main Methods:

  • Review of case reports and clinical observations regarding kernicterus.

Related Experiment Videos

  • Discussion of factors contributing to the apparent rise in incidence.
  • Emphasis on clinical vigilance and the role of diagnostic tools.

    • Main Results:

    • An apparent increase in kernicterus cases reported in the 1990s.
    • Identification of potential contributing factors including decreased awareness and early discharge.
    • Highlighting the lack of precise tools to predict bilirubin neurotoxicity in vulnerable infants.

    Conclusions:

    • Physicians must remain vigilant in evaluating jaundiced newborns, despite most cases not requiring aggressive treatment.
    • Transcutaneous bilirubin measurement offers a non-invasive method to reduce invasive testing.
    • Prompt recognition and emergency phototherapy are critical for jaundiced infants exhibiting signs of neurotoxicity, alongside further evaluation.