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Updated: Sep 29, 2026
Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System
Published on: October 5, 2015
CD4(+) T cell levels are decreased during active CMV infection in kidney transplant recipients
Sahar Essa1, Alexander S Pacsa, Raj Raghupathy
1Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Kuwait 13110, Kuwait. sahar@hsc.kuniv.edu.kw
Abstract:
The numbers of T lymphocytes and T cell subsets (CD2(+), CD3(+), CD4(+), CD8(+)), activated T cells (CD26(+)), B cells (CD19(+)), granulocytes (CD15(+)) and natural killer cells (CD16/56) were monitored by flow cytometry in 79 kidney transplant recipients, 35 of whom had cytomegalovirus infection. The percentages of these cells were correlated with viral load, as determined by cytomegalovirus antigenemia. Development of cytomegaloviral infection coincided with a significant reduction in the percentages of CD4(+) (P < 0.005) and CD3(+) (P < 0.05) cells. Monitoring of lymphocyte subsets may provide useful information on immunological events during cytomegaloviral infection.
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