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A hepatitis B surface antigen mutant that lacks the antigenic loop region can self-assemble and interact with the
Brendan O'Malley1, David Lazinski
1Department of Molecular Biology and Microbiology and the Raymond and Beverly Sackler Research Foundation Laboratory, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Journal of Virology
|September 5, 2002
Abstract:
A novel hepatitis B virus surface antigen mutant harboring a deletion of most of the major antigenic loop region was competent for self-assembly and secretion. Although the mutant protein was competent for interaction with and incorporation of free large hepatitis delta antigen, it was partially defective in hepatitis delta virus RNP incorporation.