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Related Experiment Videos

Processive and nonprocessive models of kinesin movement.

Sharyn A Endow1, Douglas S Barker

  • 1Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. endow001@mc.duke.edu

Annual Review of Physiology
|September 5, 2002
PubMed
Summary

Kinesin motor proteins convert ATP energy into movement along microtubules. Their conserved structures and biochemical properties across species inform models of cellular transport mechanisms.

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Molecular Motors

Background:

  • Kinesin proteins are essential molecular motors that utilize ATP hydrolysis to generate force and movement along microtubules.
  • These motors are conserved across diverse species, playing critical roles in various cellular functions.
  • Understanding kinesin mechanisms is key to comprehending intracellular transport.

Purpose of the Study:

  • To review the current understanding of kinesin motor protein function.
  • To discuss the biochemical properties and structural insights into kinesin movement.
  • To explore different models explaining kinesin's processive and nonprocessive motility.

Main Methods:

  • Review of biochemical properties of kinesin and its homologues.
  • Analysis of recently solved three-dimensional structures of kinesin motors.

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  • Discussion of established models for kinesin movement along microtubules.

    • Main Results:

    • Kinesin motors exhibit high sequence conservation in their motor domains across species.
    • Biochemical data and structural information provide mechanistic insights into kinesin motility.
    • Several models, including hand-over-hand, inchworm, and biased diffusion, explain kinesin movement.

    Conclusions:

    • Kinesin's conserved structure and biochemical activity are fundamental to its function as a microtubule motor.
    • Structural and biochemical studies are crucial for elucidating the mechanisms of intracellular transport.
    • Further research into kinesin models will enhance our understanding of cellular mechanics.