Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

WASp in immune-system organization and function.

Adrian J Thrasher1

  • 1Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. a.thrasher@ich.ucl.ac.uk

Nature Reviews. Immunology
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic activity of a hematopoietic stem cell-delivered cell-penetrating frataxin in Friedreich's ataxia models.

Cell reports. Medicine·2026
Same author

Anti-CD45 PBD-based antibody-drug conjugates are effective targeted conditioning agents for gene therapy and stem cell transplant.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Long-term efficacy and safety results of betibeglogene autotemcel gene therapy for transfusion-dependent β-thalassemia.

Blood·2026
Same author

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1.

Obstetrical & gynecological survey·2025
Same author

Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1.

Obstetrical & gynecological survey·2025
Same author

Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency.

The New England journal of medicine·2025
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

The Wiskott-Aldrich syndrome protein (WASp) is vital for immune cell function by controlling actin reorganization. Dysregulation of WASp leads to immune system disorders like Wiskott-Aldrich syndrome.

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Immune system regulation relies on dynamic actin reorganization.
  • The Wiskott-Aldrich syndrome protein (WASp) family is key in cytoskeletal organization.
  • WASp proteins are essential effectors of Rho GTPases and activators of the Arp2/3 complex.

Purpose of the Study:

  • To highlight the critical role of WASp in immune system pathways.
  • To explain the link between WASp function and immune dysregulation.

Main Methods:

  • This study reviews the known functions and pathways involving WASp.
  • It examines the molecular mechanisms of WASp in actin dynamics.

Main Results:

  • WASp is intimately involved in numerous immune system pathways.

Related Experiment Videos

  • WASp mediates dynamic actin reorganization in response to cell membrane signals.

    • Conclusions:

    • WASp is a crucial regulator of immune cell function.
    • Defects in WASp-mediated pathways cause Wiskott-Aldrich syndrome.