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No association between the neuronal nitric oxide synthase gene polymorphism and Alzheimer Disease
Ying-Jay Liou1, Chen-Jee Hong, Hsiu-Chih Liu
1Section of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, Republic of China.
American Journal of Medical Genetics
|September 5, 2002
Abstract:
Nitric oxide synthase (NOS) has been implicated in the pathogenesis of Alzheimer disease (AD). To examine the role of the neuronal NOS (nNOS) gene in AD, patients (n = 139) and control subjects (n = 101) were genotyped for the nNOS dinucleotide polymorphism. No association was demonstrated for AD and this particular nNOS polymorphism.