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Malignant McLeod myopathy.

Hans H Jung1, Sebastian Brandner

  • 1Department of Neurology, University Hospital, Zürich 8091, Switzerland. hans.jung@nos.usz.ch

Muscle & Nerve
|September 5, 2002
PubMed
Summary
This summary is machine-generated.

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McLeod syndrome patients with underlying myopathy may develop severe rhabdomyolysis, especially with agitation or clozapine. Careful monitoring of creatine kinase levels is crucial for early detection and management.

Area of Science:

  • Neurology
  • Genetics
  • Clinical Medicine

Background:

  • McLeod neuroacanthocytosis syndrome is an X-linked disorder.
  • Mild myopathy is a frequent clinical feature of McLeod syndrome.

Observation:

  • A patient with McLeod syndrome and subclinical myopathy experienced severe rhabdomyolysis and renal insufficiency.
  • This occurred after excessive motor restlessness during a psychotic state and a single dose of clozapine.
  • Other potential causes of rhabdomyolysis were ruled out.

Findings:

  • McLeod myopathy appears to predispose individuals to severe rhabdomyolysis.
  • This severe condition, potentially life-threatening, should be recognized as part of the McLeod syndrome spectrum.
  • Persistent mild elevation of serum creatine kinase levels was noted, attributed to the underlying myopathy.

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Implications:

  • Serum creatine kinase monitoring is recommended for McLeod syndrome patients.
  • Increased vigilance is advised for patients with hyperkinetic movement disorders or those on neuroleptic medication.
  • Recognition of rhabdomyolysis as a complication can guide clinical management and improve patient outcomes.