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[The in vitro release kinetics of Daunorubicin polybutylcyanoacrylate nanoparticles]
Abstract:
The in vitro release kinetics of Daunorubicin Polybutylcyanoacrylate Nanoparticles(DNR-PBCA-NP) was studied by dynamic dialysis system. The concentration of Daunorubicin was determined by spectrophotometry. The result showed the in vitro release kinetics of DNR-PBCA-NP could be well characterized by a biexponential equation. There were two phases in the process of drug release. The initial phase was a fast release phase (the burst effect). The second phase was a slow release phase.
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