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[Effect of curcumin on the proliferation of murine CFU-GM and WEHI-3B cells]
1Research Laboratory of Blood Physiology, Hunan Medical University, Changsha 410078.
Objective:
To evaluate the effect of curcumin on the proliferation of hematopoietic progenitor cells or leukemic stem cells.
Methods:
Mouse bone marrow cells (colony forming unit-granulocyte and macrophage, CFU-GM) and WEHI-3B cells were observed using the colony assays.
Results:
The curcumin significantly inhibited the proliferation of both CFU-GM and WEHI-3B cells in a dose-dependent manner ranging from 10(-8) to 10(-4) mol.L-1; their IC50S were 1.036 x 10(-5) mol.L-1 and 1.220 x 10(-6) mol.L-1 of curcumin respectively.
Conclusion:
The proliferation of murine CFU-GM and WEHI-3B cells can be suppressed by curcumin. The inhibitory effect of curcumin on the proliferation of WEHI-3B cells is stronger than that of CFU-GM.
