[Clinical significance of P-glycoprotein and CD34 expression of acute leukemia]

The expression of P-glycoprotein(P-170) and CD34 was detected in the bone marrow mononuclear cells of 30 patients with acute leukemia by immunocytochemical technique using JSB-1 and Tük 3 monoclonal antibody. The results were that expression of P-170 and CD34 had no significant difference between acute nonlymphoblastic leukemia and acute lymphoblastic leukemia(P > 0.05). The clinical therapeutic effect was poor in P-170 or CD34 positive patients and had significant difference compared with those negative patients(P < 0.05). Judgments of therapeutic effect for acute leukemia can be improved by detecting the expression of P-170 and CD34 simultaneously.