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A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Published on: March 29, 2024

[Effect of puerarin on heart function and serum oxidized-LDL in the patients with chronic cardiac failure]

S Duan¹, Y F Li, X L Luo

¹Department of Cardiovascular Medicine, Second Affiliated Hospital, Hunan Medical University, Changsha 410011.

Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University

|September 6, 2002

Abstract

Objective:

To observe the effect of puerarin on heart function and serum oxidized-LDL(ox-LDL) in patients with chronic cardiac failure.

Methods:

Seventy-eight patients with chronic cardiac failure were randomly divided into two groups, regular group (R) and regular + puerarin group (P). All patients in two groups received conventional treatment with inotropic agents, diuretic, and vasodilator, etc. The patients in the P group took puerarin 400 mg.d-1 for 10 days.

Results:

After treatment, the clinical heart function of the patients in the two groups was improved, but there was no significant difference between them; the left ventricular ejection fraction (EF) of patients in the P group was higher than that in the R group(P < 0.05); and serum ox-LDL level was significantly decreased in the P group patients, but that was no change in the R group patients(P < 0.05).

Conclusion:

Puerarin may improve the clinical heart function, increase the left ventricular ejection, meanwhile, it may decrease the level of ox-LDL.

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