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Modulation of axonal regeneration in neurodegenerative disease: focus on Nogo
1Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA. Stephen.Strittmatter@yale.edu
Journal of Molecular Neuroscience : MN
|September 6, 2002
Abstract:
Recent work has demonstrated that axonal regeneration in the central nervous system is limited by myelin-derived Nogo binding to an axonal Nogo Receptor. The Nogo system appears to have a physiologic role in regulating structural plasticity. The possibility that the Nogo system contributes to pathologic and compensatory plasticity in Alzheimer's Disease is considered.
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