Development of indole-3-propionic acid (OXIGON) for Alzheimer's disease

Paul E Bendheim¹, Burkhard Poeggeler, Eyal Neria

¹Minden BioPharmaceuticals, Ltd, Jerusalem, Israel. pbendheim@mindset.co.il

|September 6, 2002

Abstract:

The accumulation of amyloid-beta and concomitant oxidative stress are major pathogenic events in Alzheimer's disease. Indole-3-propionic acid (IPA, OXIGON) is a potent anti-oxidant devoid of pro-oxidant activity. IPA has been demonstrated to be an inhibitor of beta-amyloid fibril formation and to be a potent neuroprotectant against a variety of oxidotoxins. This review will summarize the known properties of IPA and outline the rationale behind its selection as a potential disease-modifying therapy for Alzheimer's disease.

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