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Cortico-Limbic Disconnection Phenotype in Chronic Central Neuropathic Pain: A Case Report

Rowaid Ahmad1, Christopher File1, Felix Fang2

  • 1Department of Neurology, The University of Texas Medical Branch, Galveston, TX.

Pain Medicine Case Reports
|May 1, 2026
PubMed
Summary

Chronic neuropathic pain after burns may involve central sensitization. Quantitative electroencephalograms (qEEGs), event-related potentials (ERPs), and neuropsychological tests can objectively assess brain changes, revealing a cortico-limbic disconnection with frontal hyperarousal.

Keywords:
Chronic neuropathic paincentral sensitizationevent-related potentials (ERPs)medicolegal evaluationneuropsychological testingqEEG

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