Related Experiment Videos
Neuro-Immune-Skin Axis: The Role of Neuropsychological Factors in Atopic Dermatitis
Ziyi Wang1,2, Dajin Shang3, Chuanying Zhao1
1From the Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, The First Hospital of China Medical University, Shenyang, China.
Abstract:
The understanding of atopic dermatitis (AD) pathogenesis is evolving beyond the barrier-immune dichotomy, with neuropsychological factors gaining prominence as a central component. This review systematically decodes the multi-level crosslink within the "brain-skin axis" in AD, encompassing recent advances in peripheral sensory neuron sensitization, central neural remodeling, and neuro-immune interactions. We elaborate on the roles of neuropeptides, cytokines, the autonomic nervous system, and the hypothalamic-pituitary-adrenal axis in the itch-scratch cycle, inflammation amplification, and mood disorders. Furthermore, we examine the influence of novel therapeutic strategies, including biologics, Janus kinase inhibitors, psychological approaches, and microbiome modulation, on these neuropsychological components. Finally, we outline future research directions, such as elucidating the molecular mechanisms of neuro-immune crosstalk, identifying relevant biomarkers, and establishing interdisciplinary diagnostic and treatment models. A deeper understanding of the role of neuropsychological factors in AD not only drives innovation in treatment strategies but also offers new perspectives for breaking the vicious cycle of "pruritus-inflammation-psychological distress."
Related Concept Videos
Gut-Brain Axis
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Inflammatory Bowel Disease III: Crohn's Disease
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Asthma-II: Pathophysiology and Classification
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Psychoneuroimmunology: Diabetes and Cancer