Anthropometric finding in Nigerian children with sickle cell disease

Sickle cell disease (SCD) subjects have been widely reported to present with various anthropometric deficits, including malocclusion and stunting, compared to their unaffected peers. This study was carried out to examine these reports in Lagos.

A hospital-based cross-sectional study was carried out in 3 outpatient SCD units of one teaching and two general hospitals. All established SCD subjects aged 1 to 18 years (n = 177) were examined on consecutive clinic days. Controls (unaffected subjects; n = 122) were obtained from well-baby and surgical emergency clinics. Facial profile, occlusion, height, weight, head and mid-upper arm (MUA) circumference measurements were noted.

A prognathic maxillary profile was found to be more prevalent in SCD subjects (21%) than controls (4%; P < .05). Class II malocclusion was found in 21% of SCD subjects compared to 2% of controls (P < .05). The overall mean height, weight and head circumference of SCD subjects and controls were not significantly different (P > .05). However, at age 18 years, the weight of the SCD group was significantly less than that of the control group (P < .05). The mean MUA circumference was significantly higher in the control group (20.04 cm +/- 3.80) than in SCD subjects (17.91 cm +/- 2.96; P < .05).

There was a higher prevalence of maxillary protrusion. and Class II malocclusion in SCD subjects than controls. Height and weight were not significantly different in both groups except at 18 years when SCD subjects weighed less than controls.