Related Experiment Video
Updated: Aug 14, 2026

Visualization of Endoplasmic Reticulum Localized mRNAs in Mammalian Cells
Published on: December 17, 2012
Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities
Tõnis Timmusk1, Kaia Palm, Natale Belluardo
1Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, S-751 23 Uppsala, Sweden. Tonis.Timmusk@helsinki.fi
Abstract:
Drosophila neurogenic gene neuralized (neu) is required for the maintenance of neuroblast cell fate and differentiation. In the present study we have characterized a mouse and a rat homologue of Drosophila neu. Mammalian neu1 encodes several C-terminal RING zinc finger proteins with one or two neuralized homology repeat (NHR) domains. Mammalian neu1 mRNAs are predominantly expressed in the nervous system and in the skeletal muscle with the highest levels in the adult. In the nervous system neu1 mRNAs are expressed in neurons and dendritically localized in several brain regions, suggesting a role of neu1 in the regulation of synaptic function. Mammalian neu1 isoforms exhibit transcription repression activities that are mediated by NHR domains and regulated by nucleocytoplasmic shuttling. In conclusion, our results suggest that mammalian neu1 is a protein with transcriptional repressor activities involved in the regulation of myo- and neurogenesis.
Related Concept Videos
MicroRNAs
RNA Polymerase II Accessory Proteins
Eukaryotic Transcription Inhibitors
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
Regulated mRNA Transport
MicroRNAs
Regulation of Expression at Multiple Steps

