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Related Experiment Videos

Personality disorders and depression.

M Fava1, A H Farabaugh, A H Sickinger

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

Psychological Medicine
|September 7, 2002
PubMed
Summary
This summary is machine-generated.

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Antidepressant treatment with fluoxetine reduced personality disorder diagnoses in major depressive disorder patients. Symptom improvement correlated with changes in some personality disorder traits, suggesting treatment effects on PD criteria.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Major depressive disorder (MDD) frequently co-occurs with personality disorders (PDs).
  • The stability of PD diagnoses in MDD patients undergoing treatment is not well understood.
  • Assessing PDs before and after antidepressant therapy can clarify diagnostic stability and treatment effects.

Purpose of the Study:

  • To evaluate the stability of PD diagnoses in outpatients with MDD.
  • To determine if antidepressant treatment with fluoxetine impacts PD diagnoses.
  • To investigate the relationship between depressive symptom improvement and changes in PD criteria.

Main Methods:

  • 384 MDD outpatients received 8 weeks of open-label fluoxetine (20 mg/day).
  • Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) assessed PDs at baseline and endpoint.

Related Experiment Videos

  • Hamilton Depression Rating Scale (HAM-D-17) measured depressive symptom severity.

    • Main Results:

    • 64% of MDD patients had at least one comorbid PD at baseline.
    • Fluoxetine treatment significantly reduced the proportion of patients meeting criteria for several PDs (e.g., avoidant, paranoid, narcissistic).
    • Reductions in depressive symptoms correlated with decreased criteria for paranoid, narcissistic, borderline, and dependent PDs.

    Conclusions:

    • PD diagnoses are prevalent in MDD patients.
    • Antidepressant treatment with fluoxetine can lead to a remission of PD diagnoses in a significant proportion of patients.
    • Changes in PD traits are linked to antidepressant efficacy, suggesting treatment may directly impact behaviors associated with PDs.