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[Observations on antibiotic sensitivity of "Pseudomonas aeruginosa" strains isolated in pediatric wards (author's
Quaderni Sclavo Di Diagnostica Clinica E Di Laboratorio
|June 1, 1979
Abstract:
It has been studied the antibiotic sensitivity of 27 Pseudomonas aeruginosa strains belonging to only two types, isolated hospitalized children and responsible of different clinical pictures. The strains were in vitro resistant to Carbenicillin, Sisomicine, Gentamycine and many other antibiotic tested, partially resistant to Tobramycin and sensitive to Amikacine, Polimixine B and Colistatin.
Insights
This study assessed Pseudomonas aeruginosa strains from hospitalized children, finding resistance to common antibiotics like Carbenicillin and Gentamicin. However, strains remained sensitive to Amikacin, Polymyxin B, and Colistin.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Clinical Pharmacy
Background:
- Pseudomonas aeruginosa is an opportunistic pathogen frequently causing hospital-acquired infections.
- Antibiotic resistance in P. aeruginosa poses a significant challenge in clinical settings, particularly in pediatric populations.
- Understanding local resistance patterns is crucial for effective treatment strategies.
Purpose of the Study:
- To determine the in vitro antibiotic sensitivity profile of Pseudomonas aeruginosa strains isolated from hospitalized children.
- To identify antibiotics to which these strains exhibit sensitivity or resistance.
Main Methods:
- Isolation and identification of 27 Pseudomonas aeruginosa strains from hospitalized children.
- In vitro antibiotic susceptibility testing using various antimicrobial agents.
- Analysis of resistance patterns against commonly used antibiotics.
Main Results:
- All 27 strains belonged to only two distinct types.
- The majority of strains demonstrated in vitro resistance to Carbenicillin, Sisomicin, and Gentamicin.
- Partial resistance was observed with Tobramycin, while Amikacin, Polymyxin B, and Colistin showed consistent sensitivity.
Conclusions:
- Pseudomonas aeruginosa strains in this pediatric cohort display significant resistance to several key antibiotics.
- Amikacin, Polymyxin B, and Colistin remain effective therapeutic options against these specific strains.
- These findings highlight the importance of targeted antibiotic selection in managing P. aeruginosa infections in hospitalized children.