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A genome screen for linkage disequilibrium in HLA-DRB1*15-positive Germans with multiple sclerosis based on 4666
Rene Goedde1, Stephen Sawcer, Stefan Boehringer
1Department of Molecular Human Genetics, Ruhr-University, Universitätsstrasse 150, 44780 Bochum, Germany. rene.goedde@ruhr-uni-bochum.de
Human Genetics
|September 7, 2002
Abstract:
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with putative autoimmune aetiology and complex genetic background. Here, we report the results of a genome screen for linkage disequilibrium (LD) by using 6000 microsatellite markers in 198 HLA-DRB1*15-positive MS patients and 198 unrelated controls (pooled DNA); 4666 analysed markers could be included in the resulting association map, from which 87 revealed significant differences between MS cases and controls.