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Related Experiment Videos

A kinase sequence database: sequence alignments and family assignment.

Oleksandr Buzko1, Kevan M Shokat

  • 1Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 513 Parnassus, San Francisco, CA 94143-0450, USA. buzko@cmp.ucsf.edu

Bioinformatics (Oxford, England)
|September 10, 2002
PubMed
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The Kinase Sequence Database (KSD) provides comprehensive information on protein kinases. It aids researchers by clustering kinase sequences and offering tools for analysis and evolutionary study.

Area of Science:

  • Biochemistry
  • Bioinformatics
  • Genomics

Background:

  • The Kinase Sequence Database (KSD) is a web-based resource.
  • It contains data on protein kinases from over 100 organisms.

Purpose of the Study:

  • To present the Kinase Sequence Database (KSD) as a comprehensive resource for protein kinase research.
  • To detail the database's structure, content, and available analytical tools.

Main Methods:

  • Profile-based clustering of non-redundant protein kinase sequences from GenBank.
  • Homology analysis within the kinase catalytic domain (250-300 residues).
  • Development of interactive sequence spreadsheets and evolutionary tree generation.

Main Results:

Related Experiment Videos

  • Identification and clustering of 290 protein kinase families.
  • Inclusion of 5,041 protein kinase sequences in the database.
  • Provision of alignments, evolutionary trees, and links to GenBank entries.

    • Conclusions:

    • KSD serves as a valuable, publicly accessible resource for protein kinase research.
    • The database facilitates sequence analysis, evolutionary studies, and novel sequence identification.
    • Interactive tools enhance the usability and analytical capabilities of the KSD.