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Esthesioneuroblastoma in children
Manjusha Kumar1, Robert J Fallon, James S Hill
1Departments of Pediatrics and Pathology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA. mkumar@iupui.edu
Journal of Pediatric Hematology/Oncology
|September 10, 2002
Summary
Esthesioneuroblastoma, a rare olfactory neuroblastoma, typically affects adults. This study examines its presentation and treatment in children, reviewing five cases and literature data.
Area of Science:
- Oncology
- Pediatric Oncology
- Pathology
Background:
- Esthesioneuroblastoma (olfactory neuroblastoma) is a rare tumor originating from the olfactory epithelium.
- While typically occurring in older individuals, pediatric cases are infrequent, with around 1,000 documented instances since 1924.
Observation:
- This study details the clinicopathologic presentation of five pediatric patients with esthesioneuroblastoma who received neoadjuvant/adjuvant chemotherapy.
- A comprehensive review of English literature was conducted to identify and analyze previously reported patients under 18 years old.
Findings:
- The research assesses the clinical presentation, treatment modalities, and outcomes specific to the pediatric age group.
- Analysis of combined case data aims to elucidate patterns and effectiveness of therapy in young patients.
Implications:
- Findings contribute to understanding esthesioneuroblastoma in children, informing diagnostic and therapeutic strategies.
- This review aids in optimizing treatment protocols and improving outcomes for pediatric patients diagnosed with this rare malignancy.