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Updated: Sep 29, 2026

Experimental Methods for Testing the Effects of Neurotrophic Peptide, ADNF-9, Against Alcohol-induced Apoptosis during Pregnancy in C57BL/6 Mice
Published on: April 24, 2013
Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus
Mi-Hyeon Jang1, Min-Chul Shin, Sae-Bin Jung
1Department of Physiology, College of Medicine, Kyung Hee University, 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701.
Abstract:
It is generally accepted that alcohol and nicotine affect learning ability and memory functions, especially in adolescents. In the present study, the effects of alcohol and nicotine on cell proliferation and apoptosis in the dentate gyrus of young rats were investigated. The results show that cell proliferation is suppressed by alcohol and nicotine. Furthermore, alcohol and nicotine increase the number of terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)-positive cells. Based on the results presented in this study, it can be suggested that alcohol- and nicotine-related impairment in learning and memory functions may be due to alcohol- and nicotine-induced suppression of new cell formation and acceleration of apoptosis, especially during adolescence.
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