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A Computer Model for the Pore of Potassium Channel: Oxygen Cage Mechanism
Shan-Rong Zhao1, Kai-Xian Chen, Yun Tang
1Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica Et Biophysica Sinica
|January 1, 1997
Abstract:
We have constructed a structural motif for the pore of voltage-gated K(+) channel by computer modeling. The model developed here predicts that the narrowest part of the pore is formed by the four carbonyl oxygens of Gly444 or Gly446, and that the ion selectivity is achieved through "oxygen cage" mechanism. Residues 447, 448 and 449 make the external entrance to the narrowest part of the pore. Of these residues, 449 and 447 are believed to interact directly with TEA. This model agrees well with many available experimental data.