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[The reproducibility of multifocal ERG recordings]
1Universitäts-Augenklinik Würzburg. t.meigen@augenklinik.uni-wuerzburg.de
Summary
Multifocal electroretinogram (mfERG) recordings show high reproducibility, even with short durations and single traces. Retest variability is comparable between sessions, indicating reliable mfERG amplitude measurements.
Area of Science:
- Ophthalmology
- Neuroscience
- Retinal Physiology
Background:
- Multifocal electroretinogram (mfERG) recordings are crucial for detecting localized retinal dysfunction.
- Assessing the reproducibility of mfERG amplitudes is essential for reliable clinical application.
Purpose of the Study:
- To evaluate the intrasessional and inter-sessional reproducibility of mfERG amplitudes.
- To investigate factors influencing mfERG amplitude reproducibility, including recording duration and trace type.
Main Methods:
- mfERGs were recorded from 6 normal subjects on two separate days using DTL electrodes.
- Relative Coefficient of Variation (RCV) quantified amplitude reproducibility.
- Effects of session type, recording duration, trace type, and amplitude definition were analyzed.
Main Results:
- Overall RCV was 6.5+/-0.4%, indicating high reproducibility.
- Significant differences in RCV were observed between hexagon traces and ring averages (p=0.018).
- A significant interaction effect was found between session type and recording duration (p=0.016).
Conclusions:
- mfERG amplitudes demonstrate high reproducibility, even with short recording durations and single hexagon traces.
- Inter-sessional mfERG recordings exhibit comparable retest variability to intrasessional recordings.
- The findings support the reliability of mfERG for assessing retinal function.