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Related Experiment Videos

Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue

George Z Rassidakis1, Dan Jones, Athanasios Thomaides

  • 1Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

American Journal of Clinical Pathology
|September 11, 2002
PubMed
Summary
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Apoptotic rate (AR) varies significantly across peripheral T-cell lymphomas (PTCLs). Enteropathy-type T-cell lymphoma and anaplastic lymphoma kinase protein (ALK)-positive ALCL exhibit the highest ARs, suggesting apoptosis plays a key role in these PTCL subtypes.

Area of Science:

  • Hematology
  • Oncology
  • Cell Biology

Background:

  • Peripheral T-cell lymphomas (PTCLs) represent a diverse category of non-Hodgkin lymphomas.
  • Apoptosis, or programmed cell death, is a critical cellular mechanism that may influence lymphomagenesis in PTCLs.

Purpose of the Study:

  • To assess the apoptotic rate (AR) in a cohort of 112 PTCLs.
  • To investigate variations in AR among different PTCL subtypes.
  • To evaluate the reliability of tissue microarrays for AR assessment.

Main Methods:

  • A tissue microarray was constructed from 112 PTCL samples.
  • A modified terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay was employed to quantify apoptotic cells.
  • AR was compared across various PTCL subtypes and morphologic features.

Related Experiment Videos

  • Tissue microarray results were validated against full tissue sections in a subset of cases.

    • Main Results:

    • The mean AR across all PTCLs was 1.47% (range, 0.06%-5.15%).
    • Significant variations in AR were observed among PTCL subtypes, with enteropathy-type T-cell lymphoma (3.06%) and anaplastic lymphoma kinase protein (ALK)-positive ALCL (2.95%) showing the highest rates.
    • Higher AR was noted in PTCLs with large cell morphology compared to small/medium cell morphology (1.66% vs 0.99%).
    • Tissue microarray-based AR assessment demonstrated favorable concordance with full tissue section analysis.

    Conclusions:

    • Apoptotic rate is a variable feature across PTCL subtypes.
    • Enteropathy-type T-cell lymphoma and ALK-positive ALCL exhibit the highest apoptotic rates.
    • Tissue microarrays provide a reliable method for assessing apoptotic rates in PTCLs.