[Gastric biopsy in the diagnosis of stomach diseases]

An analysis of changes in the mucosa typical of chronic ulcer, polyp, gastric cancer and chronic gastritis was carried out on the basis of gastrobiopsy specimens. All these diseases were characterized by rearrangement of the mucosa, which manifested itself in atrophy of the specialized glandular parenchyma, proliferation of pavement-cuboidal and colomnar epithelium, intestinal metaplasia, and hypermucoidization of the stomach glands. Certain difficulties presents diagnosis based on gastrobiopsy specimens of cricoid, granulating and trabecular cancer. Of a decisive significance in the diagnosis of carcinoma is the presence in the mucosa proper of cricoid cells, which are stained with mucicarmine and give positive Schick-reaction, or pironinophilic epithelial ligaments not forming glandular lumens. The author analyses, on the basis of his personal experience, cases of hyperdiagnosis of gastric carcinoma. Proliferating glandular parenchyma, proliferation of pavement-cuboidal and colomnar epithelium, epithelial regenerates, and elements of the granulation tissue from the fundus of an ulcerative defect were taken for cancer.