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Odontogenic cyst with verrucous proliferation.
Michael J Aldred1, Anna A Talacko, Peter G Allan
1Dorevitch Pathology, Melbourne, Australia. oralpathologists@maynegroup.com
Summary
A rare odontogenic cyst variant with verrucous features was identified in a young patient. Despite koilocyte-like cells suggesting a viral cause, human papillomavirus (HPV) was not detected.
Area of Science:
- Oral pathology
- Histopathology
- Odontogenic cysts
Background:
- Odontogenic cysts are developmental or acquired lesions of the jaws.
- Verrucous lesions in the oral cavity can have various etiologies, including viral infections.
- Accurate histopathological diagnosis is crucial for appropriate management.
Observation:
- A unique case of an odontogenic cyst presenting with verrucous proliferation in a 13-year-old girl.
- Histological examination revealed lumenal verrucous projections, hypergranulosis, and koilocyte-like cells.
- These features raised suspicion for a viral etiology, specifically human papillomavirus (HPV).
Findings:
- Immunohistochemistry and polymerase chain reaction (PCR) amplification tests were negative for HPV.
- The odontogenic cyst variant with verrucous proliferation appears to be a novel entity.
- The koilocyte-like changes were not attributable to HPV infection in this case.
Implications:
- This case expands the histopathological spectrum of odontogenic cysts.
- It highlights the importance of considering non-viral causes for verrucous lesions in odontogenic cysts.
- Further research may be needed to elucidate the etiology of this distinctive cyst variant.