Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell surface immunoglobulin receptors in B cell development.

Kelly A Pike1, Michael J H Ratcliffe

  • 1Department of Immunology, University of Toronto, 1 King's College Circle, Toronto, Ont., Canada M5S 1A8.

Seminars in Immunology
|September 11, 2002
PubMed
Summary

Surface immunoglobulin (sIg) receptors are vital for B cell development across species. This review examines how sIg components regulate B cell development in various experimental models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First-In-Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT-02 Freebase, a CNS-Penetrant NLRP3 Inhibitor.

Clinical and translational science·2026
Same author

Reducing hERG Inhibition in the Design of Potent and Bioavailable Indazole cGAS Inhibitors.

ACS medicinal chemistry letters·2026
Same author

Structural insight into the cGAS active site explains differences between therapeutically relevant species.

Communications chemistry·2025
Same author

Discovery of Potent and Orally Bioavailable Pyrimidine Amide cGAS Inhibitors via Structure-Guided Hybridization.

ACS medicinal chemistry letters·2024
Same author

Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.

Frontiers in immunology·2018
Same author

Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNγ signaling.

Oncoimmunology·2017

Area of Science:

  • Immunology
  • Developmental Biology
  • Molecular Biology

Background:

  • Surface immunoglobulin (sIg) receptors are crucial for B cell development, acting as a conserved checkpoint.
  • The sIg receptor complex consists of ligand-binding extracellular chains and signal-transducing Igalpha/Igbeta heterodimers.

Purpose of the Study:

  • To review the regulatory functions of different components of the sIg receptor complex.
  • To analyze these functions during early B cell development.
  • To compare findings across experimental systems from evolutionarily distinct species.

Main Methods:

  • Review of experimental systems studying B cell development.
  • Analysis of avian and murine models.
  • Assessment of regulatory functions of sIg receptor components.

Related Experiment Videos

Main Results:

  • The sIg receptor complex plays a conserved role in B cell development.
  • Different components of the sIg receptor complex exhibit distinct regulatory functions.
  • Comparative analysis across species highlights conserved and divergent mechanisms.

Conclusions:

  • Understanding the regulatory roles of sIg components is essential for B cell development.
  • Experimental models from diverse species provide insights into conserved developmental checkpoints.
  • Further research into sIg receptor function can elucidate mechanisms of immune system development.