Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Controlling hypertension in diabetes.

¹Steno Diabetes Center, Gentofte, Denmark.

Acta Diabetologica

|September 12, 2002

Summary

Type 2 diabetes patients with high blood pressure face significant cardiovascular and kidney risks. Aggressive blood pressure control, often requiring combination therapy with ACE inhibitors and other antihypertensives, is crucial for managing these risks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estimated GFR: Are There Limits to Its Utility?: Monitoring Kidney Function in Type 2 Diabetic Patients with Incipient and Overt Diabetic Nephropathy. Diabetes Care 29: 1024-1030, 2006.

Journal of the American Society of Nephrology : JASN·2023

Same author

Effect of insulin analogues on frequency of non-severe hypoglycaemia in patients with type 1 diabetes prone to severe hypoglycaemia: The HypoAna trial.

Diabetes & metabolism·2016

Same author

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1.

Diabetologia·2013

Same author

Retinal microaneurysm count predicts progression and regression of diabetic retinopathy. Post-hoc results from the DIRECT Programme.

Diabetic medicine : a journal of the British Diabetic Association·2011

Same author

A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.

Diabetologia·2010

Same author

Effect of carbon monoxide exposure on capillary permeability to albumin and α₂-macroglobulin.

Scandinavian journal of clinical and laboratory investigation·2010

Area of Science:

Cardiology
Endocrinology
Nephrology

Background:

Type 2 diabetes (T2D) patients are highly susceptible to vascular damage from hypertension.
The co-occurrence of hypertension and T2D elevates the risk of cardiovascular events and end-stage renal disease.
Established antihypertensive therapies, including ACE inhibitors and CCBs, show benefits in T2D patients.

Purpose of the Study:

To review the established benefits of antihypertensive therapies in T2D patients.
To emphasize the importance of aggressive blood pressure lowering in this population.
To recommend combination therapy for achieving target blood pressure levels.

Main Methods:

Review of placebo-controlled trials and major clinical trials.
Analysis of data from the UK Prospective Diabetes Study.
Evaluation of treatment strategies for hypertensive patients with T2D.

Main Results:

Antihypertensive drugs (ACE inhibitors, CCBs) demonstrate therapeutic benefits in T2D.
Aggressive blood pressure lowering significantly reduces T2D complications, as shown in the UK Prospective Diabetes Study.
Monotherapy often fails to achieve recommended blood pressure targets (<130/85 mm Hg).

Conclusions:

Combination therapy, particularly ACE inhibitors with CCBs, diuretics, or beta-blockers, is recommended for hypertensive T2D patients.
Tight blood pressure control is essential for mitigating diabetes-related complications.
Multidrug regimens are necessary for achieving optimal blood pressure management in T2D.

Related Experiment Videos