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Related Concept Videos

Hormonal Regulation01:33

Hormonal Regulation

The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Regulation of Hormone Secretion01:19

Regulation of Hormone Secretion

Regulation of hormone secretion is a finely tuned orchestration driven by various types of stimuli, encompassing neural, humoral, and hormonal signals. Environmental cues instigate neural stimuli, where action potentials traverse nerve fibers to reach their designated targets. An illustrative scenario is the body's response to stress, wherein the sympathetic nervous system releases epinephrine from the adrenal glands, inducing the well-known 'fight or flight' reaction.
Humoral stimuli,...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.

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Related Experiment Video

Updated: Jun 29, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

[Hormonal interaction and hair growth].

R Hoffmann1

  • 1Department of Dermatology, Philipp University, Marburg, Germany.

Annales De Dermatologie Et De Venereologie
|September 12, 2002
PubMed
Summary
This summary is machine-generated.

Androgenetic alopecia (AGA) involves genetically predisposed hair loss dependent on dihydrotestosterone (DHT). Understanding local androgen metabolism in dermal papilla cells offers potential pharmaceutical targets for treating AGA and hirsutism.

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Area of Science:

  • Dermatology and Endocrinology
  • Molecular Biology
  • Genetics

Context:

  • Androgenetic alopecia (AGA) is the most common hair loss condition, affecting both men and women.
  • While genetic predisposition is key, the specific genes remain unidentified.
  • The hormonal influence on hair growth, particularly dihydrotestosterone (DHT), is better understood.

Purpose:

  • To explore the role of local androgen metabolism within hair follicles in the pathogenesis of AGA.
  • To investigate the function of steroidogenic enzymes in the dermal papilla (DP) and their link to androgen sensitivity.
  • To identify potential pharmaceutical targets for treating AGA and hirsutism based on intrafollicular androgen modification.

Summary:

  • AGA is a DHT-dependent process characterized by hair follicle miniaturization.
  • Local androgen metabolism, involving the conversion of androgens within the hair follicle, is crucial.
  • Steroidogenic enzymes like STS, 17beta-HSD, 3beta-HSD, 3alpha-HSD, and 5alpha-R in the DP play a significant role in regulating androgen action.

Impact:

  • Understanding these molecular pathways can lead to novel therapeutic strategies for hair loss disorders.
  • Identifying specific enzymes offers targets for pharmaceutical intervention in AGA and hirsutism.
  • This research contributes to understanding the differential sensitivity of hair follicles to androgens across the body.