[Partial androgen deficiency in the aging male: diagnosis and therapy]

After the fourth decade, androgen serum level fall while the binding capacity for testosterone, the sex hormone binding globulin, raises. Clinical symptoms and hypogonadism define the syndrome of the partial androgen deficiency of the aging male (PADAM). Testosterone substitution may be performed by intramuscular injections, oral or transdermal testosterone application. Each patient should undergo urological evaluation before starting a testosterone replacement therapy. Life style drugs should not be used according the currently rational data. Well balanced nutrition, physical training and an active social and sexual life are important factors to achieve a healthy aging.