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Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells
Chikako Murakami1, Yuki Hirakawa, Hiroshi Inui
1Faculty of Nutrition, Kobe Gakuin University, Japan.
Bioscience, Biotechnology, and Biochemistry
|September 13, 2002
Abstract:
Tea catechins inhibited TBARS accumulation in HepG2 cells, the order of effectiveness being (-)-epigallocatechin gallate (EGCG) > (-)-epigallocatechin (EGC) > or = (-)-epicatechin gallate (ECG) > (-)-epicatechin (EC). EGCG and EGC protected the depletion of alpha-tocopherol in the cells, and the glutathione content was enhanced by all four catechins. Moreover, all four catechins suppressed the formation of glutathione disulfide and the activation of glutathione peroxidase induced by tert-butylated hydroperoxide.