Jove
Visualize
Contact Us

Related Experiment Videos

[Transitional elements and free radicals].

J Racek1, J Eiselt, K Opatrný

  • 1Ustav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzen. racek@fnplzen.cz

Casopis Lekaru Ceskych
|September 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

False-Positive Cardiac Troponin Elevations in Skeletal Muscle Disease: Clinical Relevance, Mechanisms, and Laboratory Approaches.

Physiological research·2025
Same author

Effect of Beer Consumption on Methylation and Redox Metabolism.

Physiological research·2022
Same author

NGAL, albumin and cystatin C during cisplatin therapy.

Physiological research·2020
Same author

Creatine Kinase and Myoglobin Levels as Indicators of Perioperative Muscle Damage during Open- and Mini-Invasive Stabilization of Thoracic and Lumbar Spine Fracture - a Prospective Randomized Study.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca·2020
Same author

Prognostic role of serum C-reactive protein in patients with advanced-stage NSCLC treated with pemetrexed.

Neoplasma·2017
Same author

Serum albumin is a strong predictor of survival in patients with advanced-stage non-small cell lung cancer treated with erlotinib.

Neoplasma·2016
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Essential metals like iron and copper can form harmful free radicals. Organisms possess protective mechanisms to manage these metals, preventing cellular damage and disease.

Area of Science:

  • Biochemistry
  • Toxicology
  • Cell Biology

Context:

  • Essential trace elements, iron and copper, can catalyze free radical formation under specific conditions.
  • Other transition metals also exhibit similar pro-oxidant behavior.
  • Organisms have evolved sophisticated defense mechanisms against metal-induced oxidative stress.

Purpose:

  • To review the role of transition metals in free radical formation.
  • To elucidate the biological mechanisms for preventing metal-induced oxidative damage.
  • To highlight the importance of iron and copper metabolism in cellular protection.

Summary:

  • Transition metals, particularly iron and copper, can generate dangerous hydroxyl radicals via single electron reactions.
  • Organisms protect themselves by binding, oxidizing, or sequestering free transition metals.

Related Experiment Videos

  • Effective management of these metals is crucial for preventing cellular damage.

    • Impact:

    • Understanding these protective mechanisms aids in predicting and preventing system breakdown.
    • This knowledge is vital for managing conditions like intravascular hemolysis and iron overload.
    • It informs strategies for preventing toxicity from oxidizing substances and metabolic disorders.