[Distribution of methionine-75Se in animals with experimental atherosclerosis treated with a protein hydrolysate]

It is well known that accumulation of methionine in the internal organs is weaker in animals with experimental atherosclerosis. On the basis of this concept the authors carried out studies on rabbits and guinea pigs with atherosclerosis, induced by cholesterol diet and treated with protein hydrolysate-hydropront in a dose of 5 ml/kg of body weight daily for rabbits and every two days for guinea pigs. Distribution of methionine 75Se was examined in the internal organs. The radioisotope in a dose of 5 microcurie was injected two hours before killing of the animals. There was a reduced accumulation of methionine 75Se in the internal organs of rabbits and guinea pigs with experimental atherosclerosis. The disturbances were increased after prolongation of cholesterol feeding. The application of protein hydrolysate considerably improved the accumulation of methionine in the treated animals compared with the untreated animals with atherosclerosis.