[Effect of a protein hydrolysate on enzymatic activity in the aorta wall in experimental atherosclerosis]

Kirk, Antonini, Weber and others have found that the activity of the specific phosphomonoesterase 5-nucleotidase is lowered. In the present study, carried out on male guinea pigs and fed with cholesterol for a period of 150 days, the authors discovered analogous change in 5-nucleotidase activity of the aortic wall. Administration of protein hydrolysate induced a statistically significant increase of the enzymic activity in the aorta of animals, fed with cholesterol. The combined treatment with protein hydrolysate and vitamins caused even more significant activation of the enzyme. The established changes in the activity of 5-nucleotidase were similar to the changes in the activity of adenylpyrophosphatase of animals under the same experimental conditions.