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Updated: Aug 12, 2026
Imaging of Estrogen Receptor-α in Rat Pial Arterioles using a Digital Immunofluorescent Microscope
Published on: November 29, 2011
[Comparative evaluation of the antiradical and antioxidant activity of estrogens and their nitro derivatives]
A I Matiushin1, V M Gukasov, V M Rzheznikov
1Molecular Pharmacology and Radiobiology Department, State Medical University, ul. Ostrovityanova 1, Moscow, 117437 Russia.
Abstract:
Estradiol, ethynylestradiol, and estradiol acetate possess antiradical activity (K7 = (1.8-2.0) x 10(-4) liter/mole sec). Nistranol exhibits antiradical properties only upon acid hydrolysis. The results of experiments with egg yolk liposomes showed evidence of a pronounced antioxidant activity of estradiol, ethynylestradiol, and estradiol nitrate, and the absence of such activity in nistranol. In the experiments on rat heart homogenates, nitroestrogens in a concentration of about 10(-4) M reduced the level of TBA-active products.
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