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A new synthesis of Neu5Ac from D-glucono-delta-lactone
Ke-Gang Liu1, Shi Yan, Yu-Lin Wu
1State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, China.
The Journal of Organic Chemistry
|September 14, 2002
Abstract:
A new route to Neu5Ac methyl ester (23) with a readily available sugar D-glucono-delta-lactone as starting material has been developed. A diastereoselective propargylation of alpha-acetamino aldehyde and a subsequent KMnO(4) oxidation of the terminal alkyne served as the key steps.